范艳华   性别：女    学历：博士    专业：化学生物学   职称：副研究员
主要研究方向：化学生物学，抗肿瘤与神经退行性疾病的新药开发
教育经历：2007.9至2011.6 湘南学院，药学专业，理学学士； 2011.9至2017.6 沈阳药科大学中药学院，天然药物化学/中药学专业，理学硕士/博士；2016.8至2017.9韩国首尔大学药学院，新药药理，公派联合培养博士。
工作经历：2017年10月-2018年4月，就职于沈阳药科大学无涯学院
2018年5月至今，就职于贵州省中国科学院天然产物化学重点实验室
代表性科研工作：

1. Yanhua Fan, Huaiwei Ding, Donghwa Kim, Duc-Hiep Bach, Ji-Young Hong, Yong-Nan Xu and Sang Kook Lee. Antitumor Activity of DFX117 by Dual Inhibition of c-Met and PI3Kα in Non-Small Cell Lung Cancer. Cancers, 2019, 11(5),627.
2. Meichen Li^#; Yanhua Fan^#; Ting Zhong; Ping Yi; Chengcheng Fan; Andong Wang; Jianyu Liu ; Yongnan Xu. The protective effects of vernicilignan A, new flavonolignan isolated from Toxicodendron vernicifluum on SH-SY5Y cells against oxidative stress-induced injury, Fitoterapia, 2019, 134: 81-87.
3. Jianyu Liu #; Yanhua Fan #; Donghwa Kim; Ting Zhong; Ping Yi; Chengcheng Fan; Andong Wang; Xiaosheng Yang; Sangkook Lee; Xuhong Ren; Yongnan Xu. Neuroprotective effect of catechins derivatives isolated from Anhua dark tea on NMDA-induced excitotoxicity in SH-SY5Y cells, Fitoterapia, 2019,137:104240.
4. Ning Wang #; Yanhua Fan #;  Chunmao Yuan; Jialei Song; Yao Yao; Wuling Liu; Babu Gajendran; Eldad Zacksenhaus; Yanmei Li; Jielin Liu**; Xiao Jiang Hao** and Yaacov Ben-David*, Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity., BMC Cancer,2019,19:764.
5. ndong Wang ^#; Yanhua Fan^#; Qing Ouyang; Cengcheng Fan; Bing Lin; Jianyu Liu ; Yongnan Xu , Antiproliferative ent-kaurane diterpenoids isolated from the roots of Zea mays L., Fitoterapia, 2019, 134: 44-49.
6. Yanhua Fan; Wei Li; Dandan Liu; Mengxuan Bai; Hongrui Song; Yongnan Xu; Sang Kook Lee; Zhipeng Zhou; Jian Wang; Huaiwei Ding. Novel 4-aminoquinazoline derivatives induce growth inhibition, cell cycle arrest and apoptosis via PI3Kα inhibition. Bioorganic & Medicinal Chemistry,2018, 26(8): 1675-1685.
7. Yanhua Fan; Jianyu Liu; Ying Bao; Dan Liu; Zhipeng Zhou; Jian Wang, Qingchun Zhao; Yongnan Xu. NSCA-1-a novel N-substituted coumalamide derivative-increases Adriamycin sensitivity in HepG2/adriamycin cells through modulating Akt/GSK-3β signaling and p53-dependant apoptotic pathway, Environmental Toxicology and Pharmacology, 2017, 49: 1-7.
8. Yanhua Fan ; Wei Li; Dandan Liu; Mengxuan Bai; Hongrui Song; Yongnan Xu; Sang Kook Lee; Zhipeng Zhou; Jian Wang; Huaiwei Ding ,Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2-a]pyridine and quinazolin-4(3H)-one derivatives as PI3Kα inhibitors, European Journal of Medicinal Chemistry,2017, 136: 95-106.
9.  Yanhua Fan; Hongyuan Lu; Li An; Cangli Wang; Zhipeng Zhou; Fan Feng; Hongda Ma; Yongnan Xu ; Qingchun Zhao. Effect of active fraction of Eriocaulon sieboldianum on human leukemia K562 cells via proliferation inhibition, cell cycle arrest and apoptosis induction., Environmental Toxicology and Pharmacology, 2016, 43: 13-20.
10. Yanhua Fan; Hongyuan Lu; Hongda Ma; Fan Feng; Xiaolong Hu; Qiao Zhang; Jian Wang; Yongnan Xu; Qingchun Zhao. Bioactive compounds of Eriocaulon sieboldianum blocking proliferation and inducing apoptosis of HepG2 cells might be involved in Aurora kinase inhibition, Food & Function, 2015,6: 3746-3759.
11. Donghwa Kim, Duc-Hiep Bach, Yan-Hua Fan, Thi-Thu-Trang Luu, Ji-Young Hong, Hyen Joo Park, and Sang Kook Lee. AXL degradation in combination with EGFR-TKI can delay and overcome acquired resistance in human non-small cell lung cancer cells. Cell Death & Disease, 2019, 10(5): 361.
12. Tangjingjun Liu; Lei Xia; Yao Yao; Chen Yan; Yanhua Fan; Babu Gajendran; Jue Yang; You-Jun Li; Juan Chen; Jorge Filmus; David E Spaner; Eldad Zacksenhaus; Xiaojiang Hao; Yaacov Ben-David. Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis. Cell Death & Disease, 2019, 10(2):117.
13. Jingjing Meng; Yanhua Fan; Mingzhi Su; Congqin Chen; Tianshu Ren; Jinhui Wang; Qingchun Zhao. WLIP derived from Lasiosphaera fenzlii Reich exhibits anti-tumor activity and induces cell cycle arrest through PPAR-γ associated pathways, International Immunopharmacology, 2014, 19(1): 37-44.
14. Ting Zhong, Min Feng, Minzhi Su, Daoping Wang, Qing Li, Shuqin Jia, Fang Luo, Haibo Wang, Enming Hu, Xiaosheng Yang**, Yanhua Fan*, Qihuzha granule attenuated LPS-induced acute spleen injury in mice via Src/MAPK/Stat3 signal pathway, Journal of Ethnopharmacology, 281 (2021) 114458.
15. Huarong Yang, Qing Li, Mingzhi Su, Fang Luo, Yahua Liu**, Daoping Wang**, Yanhua Fan*, Design, synthesis, and biological evaluation of novel 6-(pyridin-3-yl) quinazolin-4(3H)-one derivatives as potential anticancer agents via PI3K inhibition. Bioorganic & Medicinal Chemistry 46, (2021) 116346.
16. Yanhua Fan, Huaiwei Ding, Donghwa Kim, Jianyu Liu, Ji-Young Hong,  Xiaosheng Yang, Sang Kook Lee. The PI3Kα inhibitor DFX24 suppresses tumor growth and metastasis in non-small cell lung cancer via ERK inhibition and EPHB6 reactivation, Pharmacological Research 160 (2020) 105147.
17. Chengcheng Fan, Ting Zhong, Huarong Yang, Ying Yang, Daoping Wang, Xiaosheng Yang, Yongnan Xu**, Yanhua Fan*. Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d] imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition, European Journal of Medicinal Chemistry 190 (2020) 112108.
18. Jin Yang, Shengcao Hu, Chunlin Wang, Junrong Song, Chao Chen, Yanhua Fan**, Yaacov Ben-David ***, Weidong Pan*. Fangchinoline derivatives induce cell cycle arrest and apoptosis in human leukemia cell lines via suppression of the PI3K/AKT and MAPK signaling pathway, European Journal of Medicinal Chemistry 186 (2020) 111898.
19. Jianyu Liu, Ting Zhong, Ping Yi, Chengcheng Fan, Zhen Zhang, Guangyan Liang,Yongnan Xu**, Yanhua Fan*. A new epigallocatechin gallate derivative isolated from Anhua dark tea sensitizes the chemosensitivity of gefitinib via the suppression of PI3K/mTOR and epithelial-mesenchymal transition, Fitoterapia 143 (2020) 104590.

主持的主要科研项目：
2020年   国家自然科学基金：逆转非小细胞肺癌EGFR-TKI耐药的新型PI3Kα/BET双靶点抑制剂的设计合成及其作用机制研究，25万元，主持；
2020年   国家自然科学基金：玉米根中靶向NMDA受体的神经保护与抗抑郁活性物质基础及作用机制的研究，34万元，主持；
 2020年 贵州省高层次留学人才创新创业择优资助重点项目：逆转非小细胞肺癌EGFR-TKI耐药的新型PI3Kα/BET双靶点抑制剂的设计合成及其作用机制研究    30万元，主持；
2019年   中国科学院西部青年学者    逆转非小细胞肺癌EGFR-TKI耐药靶向抑制剂的发现及其作用机制的研究，15万元，主持；
2019年   贵州省科技基金    喹唑啉酮类衍生物（DFX24）逆转非小细胞肺癌吉非替尼耐药的作用机制研究，10万元，主持；
以第一发明人申请的国家发明专利：

1. 范艳华、钟婷、许永男、刘建宇，漆树中黄烷类成分提取物制备方法及其产品和应用. 申请号：CN202110176536.9，公开号：CN112972511A.
2.  范艳华；许永男；刘建宇；钟婷，一种玉米根提取物及其制备方法和应用，

申请号：CN202010483820.6，公开号：CN111558007A。
（3）：范艳华；樊成成；许永男；钟婷；阳华容，6-(2-氨基-1H-苯并[d]咪唑-6-基)喹唑啉-4(3H)-酮类化合物，申请号：CN201911010004.7，公开号：CN110655505A。
（4）范艳华；阳华容；李青，6-(吡啶-3-基) 喹唑啉-4(3H)-酮类衍生物和制备及其应用，申请号：202110786863.6。
（5）范艳华；阳华容；苏明智，吡啶并咪唑取代的喹唑啉酮衍生物及其合成方法和应用，申请号：202110779355.5。
（6）范艳华；钟婷；苏明智；杨小生；王道平，芪斛楂颗粒在制备抗急性肺损伤药物中的而应用，申请号：202110767192.9。
 
团队成员
苏明智   
苏明智个人基本信息：
2012.03-2017.02 韩国釜山国立大学药学院，药学专业，博士；
2008.09-2011.07 沈阳药科大学 天然药物化学专业 硕士；   
2004.09-2008.07 齐齐哈尔大学 制药工程专业 学士；
代表性科研工作：

1. Su, M.# ; Zhao, C. #; Li, D.; Cao, J.; Ju, Z.; Kim, E. L.; Jung, Y.-S.; Jung, J. H.^* ;  Viriditoxin Stabilizes Microtubule Polymers in SK-OV-3 Cells and Exhibits Antimitotic and Antimetastatic Potential. Marine Drugs 2020, 18(9): 445. 
2. Ju, Z. # ; Su, M. # ; Hong, J.; Kim, E. L.; Jung, J. H. ^*, Anti-inflammatory effects of an optimized PPAR-γ agonist via NF-κB pathway inhibition. Bioorganic Chemistry 2020, 96, 103611.
3. Ju, Z. # ; Su, M. # ; Hong, J.; Kim, E. L.; Moon, H. R.; Chung, H. Y.; Kim, S.; Jung, J. H. ^*, Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites. European journal of medicinal chemistry 2019, 180, 86-98.
4. Ju, Z. # ; Su, M. # ; Hong, J.; Ullah, S.; Kim, E. L.; Zhao, C.-H.; Moon, H. R.; Kim, S.; Jung, J. H. ^*, Design of PPAR-γ agonist based on algal metabolites and the endogenous ligand 15-deoxy-Δ12, 14-prostaglandin J2. European journal of medicinal chemistry 2018, 157, 1192-1201.
5. Su, M. #; Cao, J. #; Huang, J.; Liu, S.; Im, D. S.; Yoo, J.-W.; Jung, J. H. ^*, The in vitro and in vivo anti-inflammatory effects of a phthalimide PPAR-γ agonist. Marine Drugs 2017, 15, (1), 7.
6. Su, M.; Li, H.; Wang, H.; Kim, E. L.; Kim, H. S.; Kim, E.-H.; Lee, J.; Jung, J. H. ^*, Stable and biocompatible cystine knot peptides from the marine sponge Asteropus sp. Bioorganic & medicinal chemistry 2016, 24, (13), 2979-2987.

钟婷
 个人信息：
2009.9至2013.7 长春中医药大学药学院，药物制剂，理学学士；
2013.9至2016.7长春中医药大学药学院，药物化学，理学硕士；
2016.8-2018.11 中南大学（劳务派遣），药学院，研究实习员；
2018.12-至今，贵州省中国科学院天然产物化学重点实验室，研究实习员。
 
(1) Ting Zhong^#, Min Feng^#, Minzhi Su, Daoping Wang, Qing Li, Shuqin Jiad, Fang Luo, Haibo Wang, Enming Hu, Xiaosheng Yang**, Yanhua Fan*. Qihuzha granule attenuated LPS-induced acute spleen injury in mice via Src/MAPK/Stat3 signal pathway. Journal of Ethnopharmacology. 2021.
(2) Chengcheng Fan, Ting Zhong, Huarong Yang, Ying Yang, Daoping Wang, Xiaosheng Yang, Yongnan Xuc **, Yanhua Fan *. Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d] imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition. European Journal of Medicinal Chemistry. 2020: 112108.
(3)  Ting Zhong, Liying Zhang, Zengyan Wang, Yue Wang, Fengmei Song, Jinghua Yu*, Rheum emodin inhibited Enterovirus 71viral replication through intervening cell cycle environment favored by virus, Acta Pharmacologica Sinica, 2017, (38): 392-401.
(4) Zengyan Wang, Ting Zhong, Yue Wang, Fengmei Song, Xiao Feng Yu, Liping Xing, Wenyan Zhang, Jing Hua Yu,Shucheng Hua , Xiao-Fang Yu*, Human enterovirus 68 interferes with the host cell cycle to facilitate viral production, Frontiers in Cellular and Infection Microbiology, 2017, 8 (7): 1-14.
(5)  Jinghua Yu#, Peiyou Ren#, Ting Zhong#, Yalin Wang, Minghui Yan, Bianbian Xue, Rui Li, Chunyan Dai, Chunyu Liu, Guang Chen*, Xiao-fang Yu*,Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma, Molecular Medicine Reports, 2015, 12 (5): 7195-720.
 
 
 
罗芳
罗芳个人基本信息： 2013.9至2017.7 山东大学海洋学院，药学，理学学士； 2017.9至2020.7 北京协和医学院（清华大学医学部），药剂学，理学硕士。
工作经历： 2020.12-至今，贵州省中国科学院天然产物化学重点实验室，研究实习员;
代表性科研工作:
1.    罗芳, 王丹,夏桂民. 抗癌药物吉西他滨纳米递送系统的研究进展[J]. 中国医药生物技术, 2019,14(1) :83-88.
2.    罗芳^#，李岩^#，郭晓茹，汪阿鹏，夏桂民. HPLC 法测定吉西他滨肉豆蔻酸酯脂质体中主药的含量[J]. 中国医药生物技术 , 2020,15(2) :144-151.
3.    孟月，王丹，王雪蕾，罗芳，郭晓茹，夏桂民. 抗肿瘤核酸药物阳离子纳米载体的研究进展[J]. 中国医药生物技术 , 2020,15(4) :418-425.
4.    Yang H^#, Li Q^#, Su M, Luo F, Liu Y, Wang D, Fan Y. Design, synthesis, and biological evaluation of novel 6-(pyridin-3-yl) quinazolin-4(3H)-one derivatives as potential anticancer agents via PI3K inhibition. Bioorg Med Chem. 2021 Aug 8;46:116346.
5. Ting Zhong^#, Min Feng^#, Minzhi Su, Daoping Wang, Qing Li, Shuqin Jiad, Fang Luo, Haibo Wang, Enming Hu, Xiaosheng Yang**, Yanhua Fan*. Journal of Ethnopharmacology. 2021.
6. 夏桂民，刘明亮，罗芳, 汪阿鹏. 提高药物抗肿瘤活性的方法，国家发明专利，专利号：ZL201910369362.0
7. 夏桂民，刘明亮，罗芳, 汪阿鹏，李岩，吕凯，王丹. 脂质组合物及提高药物抗肿瘤活性的方法，国家发明专利，专利号：ZL201910369077.9